diff --git a/RedfishPkg/Include/Library/RedfishHostInterfaceLib.h b/RedfishPkg/Include/Library/RedfishHostInterfaceLib.h
index 22a8f9283c..4b13282727 100644
--- a/RedfishPkg/Include/Library/RedfishHostInterfaceLib.h
+++ b/RedfishPkg/Include/Library/RedfishHostInterfaceLib.h
@@ -3,6 +3,7 @@
 
   (C) Copyright 2020 Hewlett Packard Enterprise Development LP<BR>
   Copyright (C) 2022 Advanced Micro Devices, Inc. All rights reserved.<BR>
+  Copyright (c) 2025, NVIDIA CORPORATION & AFFILIATES. All rights reserved.
 
   SPDX-License-Identifier: BSD-2-Clause-Patent
 
@@ -74,4 +75,17 @@ RedfishPlatformHostInterfaceNotification (
   OUT EFI_GUID  **InformationReadinessGuid
   );
 
+/**
+  Get USB Serial Number.
+
+  @param[OUT] SerialNumber      Pointer to retrieve complete serial number.
+
+  @retval EFI_SUCCESS         Serial number is returned.
+  @retval Others              Failed to get the serial number.
+**/
+EFI_STATUS
+RedfishPlatformHostInterfaceSerialNumber (
+  OUT CHAR8  **SerialNumber
+  );
+
 #endif
diff --git a/RedfishPkg/Library/PlatformHostInterfaceBmcUsbNicLib/PlatformHostInterfaceBmcUsbNicLib.c b/RedfishPkg/Library/PlatformHostInterfaceBmcUsbNicLib/PlatformHostInterfaceBmcUsbNicLib.c
index 5c3f8f9c50..a6818c6d23 100644
--- a/RedfishPkg/Library/PlatformHostInterfaceBmcUsbNicLib/PlatformHostInterfaceBmcUsbNicLib.c
+++ b/RedfishPkg/Library/PlatformHostInterfaceBmcUsbNicLib/PlatformHostInterfaceBmcUsbNicLib.c
@@ -3,6 +3,7 @@
   of USB NIC Device exposed by BMC.
 
   Copyright (C) 2023 Advanced Micro Devices, Inc. All rights reserved.
+  Copyright (c) 2025, NVIDIA CORPORATION & AFFILIATES. All rights reserved.
 
   SPDX-License-Identifier: BSD-2-Clause-Patent
 
@@ -1366,3 +1367,20 @@ RedfishPlatformHostInterfaceNotification (
   DEBUG ((DEBUG_ERROR, "%a: Something wrong when look for BMC USB NIC.\n", __func__));
   return Status;
 }
+
+/**
+  Get USB device serial number.
+
+  @param[out] SerialNumber    Pointer to retrieve complete serial number.
+                              It is the responsibility of the caller to free the allocated
+                              memory for serial number.
+  @retval EFI_SUCCESS         Serial number is returned.
+  @retval Others              Failed to get the serial number
+**/
+EFI_STATUS
+RedfishPlatformHostInterfaceSerialNumber (
+  OUT CHAR8  **SerialNumber
+  )
+{
+  return EFI_UNSUPPORTED;
+}
diff --git a/RedfishPkg/Library/PlatformHostInterfaceLibNull/PlatformHostInterfaceLibNull.c b/RedfishPkg/Library/PlatformHostInterfaceLibNull/PlatformHostInterfaceLibNull.c
index 40642469c9..b9eca10229 100644
--- a/RedfishPkg/Library/PlatformHostInterfaceLibNull/PlatformHostInterfaceLibNull.c
+++ b/RedfishPkg/Library/PlatformHostInterfaceLibNull/PlatformHostInterfaceLibNull.c
@@ -3,6 +3,7 @@
 
   (C) Copyright 2020 Hewlett Packard Enterprise Development LP<BR>
   Copyright (C) 2022 Advanced Micro Devices, Inc. All rights reserved.<BR>
+  Copyright (c) 2025, NVIDIA CORPORATION & AFFILIATES. All rights reserved.
 
   SPDX-License-Identifier: BSD-2-Clause-Patent
 
@@ -75,3 +76,20 @@ RedfishPlatformHostInterfaceNotification (
 {
   return EFI_UNSUPPORTED;
 }
+
+/**
+  Get USB device serial number.
+
+  @param[out] SerialNumber    Pointer to retrieve complete serial number.
+                              It is the responsibility of the caller to free the allocated
+                              memory for serial number.
+  @retval EFI_SUCCESS         Serial number is returned.
+  @retval Others              Failed to get the serial number
+**/
+EFI_STATUS
+RedfishPlatformHostInterfaceSerialNumber (
+  OUT CHAR8  **SerialNumber
+  )
+{
+  return EFI_UNSUPPORTED;
+}
diff --git a/RedfishPkg/RedfishHostInterfaceDxe/RedfishHostInterfaceDxe.c b/RedfishPkg/RedfishHostInterfaceDxe/RedfishHostInterfaceDxe.c
index 02d5f14bd2..cc929f2f42 100644
--- a/RedfishPkg/RedfishHostInterfaceDxe/RedfishHostInterfaceDxe.c
+++ b/RedfishPkg/RedfishHostInterfaceDxe/RedfishHostInterfaceDxe.c
@@ -7,12 +7,13 @@
   Copyright (c) 2019, Intel Corporation. All rights reserved.<BR>
   (C) Copyright 2020 Hewlett Packard Enterprise Development LP<BR>
   Copyright (C) 2022 Advanced Micro Devices, Inc. All rights reserved.<BR>
-  Copyright (c) 2023, NVIDIA CORPORATION & AFFILIATES. All rights reserved.
+  Copyright (c) 2023 - 2025, NVIDIA CORPORATION & AFFILIATES. All rights reserved.
   Copyright (c) 2023, Ampere Computing LLC. All rights reserved.<BR>
 
   SPDX-License-Identifier: BSD-2-Clause-Patent
 
 **/
+#include <Base.h>
 #include <Uefi.h>
 #include <Library/BaseLib.h>
 #include <Library/BaseMemoryLib.h>
@@ -54,8 +55,12 @@ RedfishCreateSmbiosTable42 (
   EFI_SMBIOS_PROTOCOL                *Smbios;
   EFI_SMBIOS_HANDLE                  MemArrayMappedAddrSmbiosHandle;
   EFI_HANDLE                         Handle;
+  CHAR8                              *SerialNumber;
+  UINTN                              SerialNumStrLen;
 
-  Handle = NULL;
+  Handle          = NULL;
+  SerialNumStrLen = 0;
+  SerialNumber    = NULL;
   //
   // Get platform Redfish host interface device type descriptor data.
   //
@@ -82,6 +87,16 @@ RedfishCreateSmbiosTable42 (
     DeviceDataLength = DeviceDescriptor->DeviceDescriptor.PciPcieDeviceV2.Length;
   } else {
     DeviceDataLength = DeviceDescriptor->DeviceDescriptor.UsbDeviceV2.Length;
+    Status           = RedfishPlatformHostInterfaceSerialNumber (&SerialNumber);
+    if (EFI_ERROR (Status)) {
+      DEBUG ((DEBUG_ERROR, "%a: Fail to get redfish host interface serial number, %r.", __func__, Status));
+      DeviceDescriptor->DeviceDescriptor.UsbDeviceV2.SerialNumberStr = 0;
+    } else {
+      if (SerialNumber != NULL) {
+        SerialNumStrLen                                                = (UINTN)AsciiStrLen (SerialNumber);
+        DeviceDescriptor->DeviceDescriptor.UsbDeviceV2.SerialNumberStr = 1;
+      }
+    }
   }
 
   //
@@ -167,6 +182,7 @@ RedfishCreateSmbiosTable42 (
                                           + DeviceDataLength
                                           + 1  /// For Protocol Record Count
                                           + CurrentProtocolsDataLength
+                                          + SerialNumStrLen
                                           + 2  /// Double NULL terminator/
                                           );
   if (Type42Record == NULL) {
@@ -208,6 +224,13 @@ RedfishCreateSmbiosTable42 (
     CurrentProtocolsDataLength
     );
 
+  //
+  // Fill in Serial Number string at the end of SMBIOS table 42
+  //
+  if (SerialNumStrLen) {
+    CopyMem (Type42Record->InterfaceTypeSpecificData + DeviceDataLength + 1 + CurrentProtocolsDataLength, SerialNumber, SerialNumStrLen);
+  }
+
   //
   // 5. Add Redfish interface data record to SMBIOS table 42
   //
@@ -259,6 +282,10 @@ ON_EXIT:
     FreePool (Type42Record);
   }
 
+  if (SerialNumber != NULL) {
+    FreePool (SerialNumber);
+  }
+
   return Status;
 }