diff --git a/CryptoPkg/Library/OpensslLib/OpensslLib.inf b/CryptoPkg/Library/OpensslLib/OpensslLib.inf
index e633d44bcb..ec945175dc 100644
--- a/CryptoPkg/Library/OpensslLib/OpensslLib.inf
+++ b/CryptoPkg/Library/OpensslLib/OpensslLib.inf
@@ -774,8 +774,8 @@
   #   -Werror=unused-but-set-variable: Warn whenever a local variable is assigned to, but otherwise unused (aside from its declaration).
   #
   GCC:RELEASE_*_*_CC_FLAGS = -DNDEBUG
-  GCC:*_*_IA32_CC_FLAGS    = -U_WIN32 -U_WIN64 $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_NOASM) -Wno-error=maybe-uninitialized -Wno-error=unused-but-set-variable
-  GCC:*_*_X64_CC_FLAGS     = -U_WIN32 -U_WIN64 $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_NOASM) -Wno-error=maybe-uninitialized -Wno-error=format -Wno-format -Wno-error=unused-but-set-variable -DNO_MSABI_VA_FUNCS
+  GCC:*_*_IA32_CC_FLAGS    = -U_WIN32 -U_WIN64 -U_MSC_VER $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_NOASM) -Wno-error=maybe-uninitialized -Wno-error=unused-but-set-variable
+  GCC:*_*_X64_CC_FLAGS     = -U_WIN32 -U_WIN64 -U_MSC_VER $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_NOASM) -Wno-error=maybe-uninitialized -Wno-error=format -Wno-format -Wno-error=unused-but-set-variable -DNO_MSABI_VA_FUNCS
   GCC:*_*_AARCH64_CC_FLAGS = $(OPENSSL_FLAGS) -Wno-error=maybe-uninitialized -Wno-format -Wno-error=unused-but-set-variable -Wno-error=format
   GCC:*_*_RISCV64_CC_FLAGS = $(OPENSSL_FLAGS) -Wno-error=maybe-uninitialized -Wno-format -Wno-error=unused-but-set-variable
   GCC:*_*_LOONGARCH64_CC_FLAGS = $(OPENSSL_FLAGS) -Wno-error=maybe-uninitialized -Wno-format -Wno-error=unused-but-set-variable
diff --git a/CryptoPkg/Library/OpensslLib/OpensslLibAccel.inf b/CryptoPkg/Library/OpensslLib/OpensslLibAccel.inf
index e5543276e4..4fc17cee16 100644
--- a/CryptoPkg/Library/OpensslLib/OpensslLibAccel.inf
+++ b/CryptoPkg/Library/OpensslLib/OpensslLibAccel.inf
@@ -2227,8 +2227,8 @@
   #                   types appropriate to the format string specified.
   #   -Werror=unused-but-set-variable: Warn whenever a local variable is assigned to, but otherwise unused (aside from its declaration).
   #
-  GCC:*_*_IA32_CC_FLAGS    = -U_WIN32 -U_WIN64 $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_IA32) -Wno-error=maybe-uninitialized -Wno-error=unused-but-set-variable
-  GCC:*_*_X64_CC_FLAGS     = -U_WIN32 -U_WIN64 $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_X64) -Wno-error=maybe-uninitialized -Wno-error=format -Wno-format -Wno-error=unused-but-set-variable -DNO_MSABI_VA_FUNCS
+  GCC:*_*_IA32_CC_FLAGS    = -U_WIN32 -U_WIN64 -U_MSC_VER $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_IA32) -Wno-error=maybe-uninitialized -Wno-error=unused-but-set-variable
+  GCC:*_*_X64_CC_FLAGS     = -U_WIN32 -U_WIN64 -U_MSC_VER $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_X64) -Wno-error=maybe-uninitialized -Wno-error=format -Wno-format -Wno-error=unused-but-set-variable -DNO_MSABI_VA_FUNCS
   GCC:*_CLANGDWARF_*_CC_FLAGS = -std=gnu99 -Wno-error=uninitialized -Wno-error=incompatible-pointer-types -Wno-error=pointer-sign -Wno-error=implicit-function-declaration -Wno-error=ignored-pragma-optimize
   GCC:*_CLANGPDB_*_CC_FLAGS = -std=c99 -Wno-error=uninitialized -Wno-error=incompatible-pointer-types -Wno-error=pointer-sign -Wno-error=implicit-function-declaration -Wno-error=ignored-pragma-optimize -Wno-error=unused-function
   # Revisit after switching to 3.0 branch
diff --git a/CryptoPkg/Library/OpensslLib/OpensslLibCrypto.inf b/CryptoPkg/Library/OpensslLib/OpensslLibCrypto.inf
index 4269228562..63c913a886 100644
--- a/CryptoPkg/Library/OpensslLib/OpensslLibCrypto.inf
+++ b/CryptoPkg/Library/OpensslLib/OpensslLibCrypto.inf
@@ -724,8 +724,8 @@
   #   -Werror=unused-but-set-variable: Warn whenever a local variable is assigned to, but otherwise unused (aside from its declaration).
   #
   GCC:RELEASE_*_*_CC_FLAGS = -DNDEBUG
-  GCC:*_*_IA32_CC_FLAGS    = -U_WIN32 -U_WIN64 $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_NOASM) -Wno-error=maybe-uninitialized -Wno-error=unused-but-set-variable
-  GCC:*_*_X64_CC_FLAGS     = -U_WIN32 -U_WIN64 $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_NOASM) -Wno-error=maybe-uninitialized -Wno-error=format -Wno-format -Wno-error=unused-but-set-variable -DNO_MSABI_VA_FUNCS
+  GCC:*_*_IA32_CC_FLAGS    = -U_WIN32 -U_WIN64 -U_MSC_VER $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_NOASM) -Wno-error=maybe-uninitialized -Wno-error=unused-but-set-variable
+  GCC:*_*_X64_CC_FLAGS     = -U_WIN32 -U_WIN64 -U_MSC_VER $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_NOASM) -Wno-error=maybe-uninitialized -Wno-error=format -Wno-format -Wno-error=unused-but-set-variable -DNO_MSABI_VA_FUNCS
   GCC:*_*_AARCH64_CC_FLAGS = $(OPENSSL_FLAGS) -Wno-error=maybe-uninitialized -Wno-format -Wno-error=unused-but-set-variable -Wno-error=format
   GCC:*_*_RISCV64_CC_FLAGS = $(OPENSSL_FLAGS) -Wno-error=maybe-uninitialized -Wno-format -Wno-error=unused-but-set-variable
   GCC:*_*_LOONGARCH64_CC_FLAGS = $(OPENSSL_FLAGS) -Wno-error=maybe-uninitialized -Wno-format -Wno-error=unused-but-set-variable
diff --git a/CryptoPkg/Library/OpensslLib/OpensslLibFull.inf b/CryptoPkg/Library/OpensslLib/OpensslLibFull.inf
index 9408d09247..ad60744e18 100644
--- a/CryptoPkg/Library/OpensslLib/OpensslLibFull.inf
+++ b/CryptoPkg/Library/OpensslLib/OpensslLibFull.inf
@@ -830,8 +830,8 @@
   #                   types appropriate to the format string specified.
   #   -Werror=unused-but-set-variable: Warn whenever a local variable is assigned to, but otherwise unused (aside from its declaration).
   #
-  GCC:*_*_IA32_CC_FLAGS    = -U_WIN32 -U_WIN64 $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_NOASM) -Wno-error=maybe-uninitialized -Wno-error=unused-but-set-variable
-  GCC:*_*_X64_CC_FLAGS     = -U_WIN32 -U_WIN64 $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_NOASM) -Wno-error=maybe-uninitialized -Wno-error=format -Wno-format -Wno-error=unused-but-set-variable -DNO_MSABI_VA_FUNCS
+  GCC:*_*_IA32_CC_FLAGS    = -U_WIN32 -U_WIN64 -U_MSC_VER $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_NOASM) -Wno-error=maybe-uninitialized -Wno-error=unused-but-set-variable
+  GCC:*_*_X64_CC_FLAGS     = -U_WIN32 -U_WIN64 -U_MSC_VER $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_NOASM) -Wno-error=maybe-uninitialized -Wno-error=format -Wno-format -Wno-error=unused-but-set-variable -DNO_MSABI_VA_FUNCS
   GCC:*_*_AARCH64_CC_FLAGS = $(OPENSSL_FLAGS) -Wno-error=maybe-uninitialized -Wno-format -Wno-error=unused-but-set-variable -Wno-error=format
   GCC:*_*_RISCV64_CC_FLAGS = $(OPENSSL_FLAGS) -Wno-error=maybe-uninitialized -Wno-format -Wno-error=unused-but-set-variable
   GCC:*_*_LOONGARCH64_CC_FLAGS = $(OPENSSL_FLAGS) -Wno-error=maybe-uninitialized -Wno-format -Wno-error=unused-but-set-variable
diff --git a/CryptoPkg/Library/OpensslLib/OpensslLibFullAccel.inf b/CryptoPkg/Library/OpensslLib/OpensslLibFullAccel.inf
index 0a0673094b..0ebbddd796 100644
--- a/CryptoPkg/Library/OpensslLib/OpensslLibFullAccel.inf
+++ b/CryptoPkg/Library/OpensslLib/OpensslLibFullAccel.inf
@@ -2388,8 +2388,8 @@
   #                   types appropriate to the format string specified.
   #   -Werror=unused-but-set-variable: Warn whenever a local variable is assigned to, but otherwise unused (aside from its declaration).
   #
-  GCC:*_*_IA32_CC_FLAGS    = -U_WIN32 -U_WIN64 $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_IA32) -Wno-error=maybe-uninitialized -Wno-error=unused-but-set-variable
-  GCC:*_*_X64_CC_FLAGS     = -U_WIN32 -U_WIN64 $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_X64) -Wno-error=maybe-uninitialized -Wno-error=format -Wno-format -Wno-error=unused-but-set-variable -DNO_MSABI_VA_FUNCS
+  GCC:*_*_IA32_CC_FLAGS    = -U_WIN32 -U_WIN64 -U_MSC_VER $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_IA32) -Wno-error=maybe-uninitialized -Wno-error=unused-but-set-variable
+  GCC:*_*_X64_CC_FLAGS     = -U_WIN32 -U_WIN64 -U_MSC_VER $(OPENSSL_FLAGS) $(OPENSSL_FLAGS_X64) -Wno-error=maybe-uninitialized -Wno-error=format -Wno-format -Wno-error=unused-but-set-variable -DNO_MSABI_VA_FUNCS
   GCC:*_CLANGDWARF_*_CC_FLAGS = -std=gnu99 -Wno-error=uninitialized -Wno-error=incompatible-pointer-types -Wno-error=pointer-sign -Wno-error=implicit-function-declaration -Wno-error=ignored-pragma-optimize
   GCC:*_CLANGPDB_*_CC_FLAGS = -std=c99 -Wno-error=uninitialized -Wno-error=incompatible-pointer-types -Wno-error=pointer-sign -Wno-error=implicit-function-declaration -Wno-error=ignored-pragma-optimize -Wno-error=unused-function
   # Revisit after switching to 3.0 branch